Multi-omic approach to evaluate the response of gilt-head sea bream (Sparus aurata) exposed to the UV filter sulisobenzone

Sulisobenzone (BP-4) is one of the benzophenone type UV filters most frequently detected in aquatic ecosystems. As a suspected endocrine disrupting compound, scarce information available yet about other molecular effects and its mechanism action. Here, we used an integrated transcriptomic metabolomic approach to improve current understanding on toxicity BP-4 towards species. Gilt-head sea bream individuals were exposed at environmentally relevant concentrations (10 ?g L-1) for 22 days. Transcriptomic analysis revealed 371 differentially expressed genes liver while identified 123 modulated features plasma 118 liver. Integration data showed disruption energy metabolism (>10 pathways related amino acids carbohydrates impacted) lipid (5 glycerophospholipids expression 3 enzymes affected), suggesting oxidative stress. We also observed, first time vivo environmental concentrations, several involved steroid thyroid hormones biosynthesis. DNA RNA synthesis was impacted by changes purine pyrimidine metabolisms. Overall, multiomic workflow presented here increases evidence exposure identifies additional modes action compounds that could have been overlooked using single omic approaches.